An in-depth coverage of pathogenic mechanisms in neurological diseases; cellular and molecular responses to brain injury and disease, neuroinflammatory diseases (e.g., multiple sclerosis), neurodegenerative diseases (e.g., Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases), neurogenetic diseases (e.g., lysosomal and peroxisomal disorders, Down's syndrome and fragile X), trauma, stroke, and viral diseases (e.g., HIV encephalitis). (Same as NURO 848, PHCL 848, PHSL 848, and NEUS 848.) Prerequisite: Advanced Neuroscience (ANAT 846, PHCL 846 or PHSL 846) or an equivalent course and consent of instructor.