Doctor of Philosophy in Medicinal Chemistry
Medicinal Chemistry Graduate Programs
Medicinal chemistry is an interdisciplinary field at the interface of chemistry and biology. It approaches important biological and health-related problems through application of fundamental principles of organic chemistry, biochemistry, natural product chemistry, and molecular pharmacology. Graduates are expected to be thoroughly familiar with the chemistry of organic compounds, including their synthesis and biosynthesis, their reactivity, and their interactions with and alteration by living systems. Research is at the heart of the program, and the department’s research activities encompass many areas of modern medicinal chemistry.
Currently, the department has 9 full-time faculty members, 10-15 graduate students on an average, about 10-15 postdoctoral associates, numerous undergraduate researchers, and an outstanding technical staff. The department is recognized nationally and internationally, and generally, our graduates pursue successful careers in the pharmaceutical industry and in academia.
Graduate Admission
Graduate students are primarily admitted to the department to pursue the Ph.D. degree. The M.S. degree and postdoctoral training are also available. An applicant wishing to enter the graduate program must have earned a bachelor’s or master’s degree in pharmacy, medicinal chemistry, chemistry, biochemistry, or a closely related field, and must have completed 1 year of organic chemistry with laboratory (equivalent to CHEM 330, CHEM 331, CHEM 335, and CHEM 336). In all cases, general admission requirements must be met.
Applications are evaluated by the graduate selection committee. Applications must be supported by 1 copy of official transcripts of all previous college and university work, both undergraduate and graduate. In addition, a resume, a statement of purpose, and 3 letters of recommendation from current or former teachers, advisors, or employers must be submitted. Students from non-English-speaking countries also must furnish proof of proficiency in English. Graduate Record Examination (GRE) general test scores are recommended but are not required, and applicants are strongly encouraged to take the subject test in chemistry as well.
The graduate selection committee makes admission decisions based on grade-point averages for previous college work (particularly in the relevant science areas), letters of recommendation, previous research or employment experience relevant to the graduate training being sought, etc. The number of applicants who can be admitted at any time varies, depending on the availability of laboratory space, research facilities, and financial support for research activities, but generally averages between 5-10 a year.
Graduate applications and all other requested application materials (transcripts, résumé, statement of purpose, recommendation letters, etc.) must be submitted online:
The University of Kansas
Department of Medicinal Chemistry
Del Shankel Structural Biology Center (SBC)
2034 Becker Drive, Room 1089
Lawrence, KS 66047
Ph.D. Degree Requirements
If credit has not already been obtained in the courses below or their equivalents, students must complete the following courses as early as is practical in the graduate program: 1 semester of Physical Chemistry, and Biochemistry. Satisfactory completion of qualifying American Chemical Society (ACS) examinations in organic chemistry and biochemistry also is required.
A comprehensive written examination is used to assess students’ knowledge of medicinal chemistry, organic chemistry, and biochemistry. This examination is administered immediately at the end of year 1 in the summer. After completing the comprehensive examination, the major part of the course work, and other requirements, the student takes an oral comprehensive examination. After completing this examination, the student prepares an original research proposal for presentation to the faculty. The final requirement for the Ph.D. is the preparation and defense of a dissertation based on original laboratory research conducted by the candidate.
Note: Contact your department or program for more information about research skills and responsible scholarship, and the current requirements for doctoral students. Current Lawrence and Edwards Campus policies on Doctoral Research Skills and Responsible Scholarship are listed in the KU Policy Library.
General requirements, such as those related to the comprehensive oral examination, the dissertation, and the dissertation defense, are listed in the Graduate Studies section of the online catalog.
Pre-Candidacy Coursework Requirements
| Code | Title | Hours |
|---|---|---|
| Required Core Courses | ||
| Advanced Medicinal Biochemistry I Fall yr1(enroll if score is <50% on ACS Biochemistry placement exam) | ||
| MDCM 710 | Chemistry of Drug Action I Fall yr1 | 4 |
| CHEM 740 | Principles of Organic Reactions Fall yr1 | 3 |
| MDCM 817 | Rigor, Reproducibility and Responsible Conduct in Research Fall yr1 multiple semesters | 3 |
| MDCM 895 | Research in Medicinal Chemistry Fall yr1 | 1 |
Workshop Fall yr1 Bibliography of Med. Chem (workshop format) | ||
| MDCM 790 | Chemistry of Drug Action II Spring yr1 | 3 |
| Elective Spring yr1 (see list, but often Physical Organic Chemistry CHEM 840) | 3 | |
| Elective Spring yr1 (see list, but often Organic Synthesis I CHEM 842) | 3 | |
| CHEM 742 | Spectroscopic Identification of Organic Compounds Summer yr1-If course is not offered, the student registers in 6 cr hr in MDCM 895 | 3 |
Exam Summer yr1-End of Year Proficiency Exam (EOY Exam) | ||
| MDCM 860 | Principles and Practice of Chemical Biology Fall yr2 | 3 |
| Elective Fall yr2 (see list below, but often Organic Synthesis II CHEM 942) | 3 | |
| MDCM 798 | Master's Literature Seminar in Medicinal Chemistry Spring yr2 | 1 |
Exam Summer yr2-Comprehensive Oral Examination | ||
| ELECTIVES | 9 | |
| A minimum of 9 credit hours of electives, composed of any combination of approved elective courses is required. Listed below are the suggested elective courses | ||
| Careers in the Biomedical Sciences (Required for TG) Fall/Spring | ||
| Physical Organic Chemistry Spring | ||
| Organic Synthesis I Spring | ||
| Organic Synthesis II Fall | ||
| Advanced Topics in Chemistry: _____ (Organic) Fall/Spring | ||
| The Molecular Biology of Cancer Fall | ||
| Rigor, Reproducibility and Responsible Conduct in Research Fall | ||
| Modern Biochemical and Biophysical Methods Spring (even years) | ||
| Introduction to Molecular Modeling Fall | ||
| Molecular Mechanisms of Neurological Disorders Fall | ||
| Drug Delivery ( Spring ) Spring | ||
| Total Hours | 39 | |
Enrollment Requirements Post-Comprehensive Exam
Upon passing the comprehensive examination, the student becomes a candidate for the Ph.D. degree and is approved to proceed with their dissertation research and project. Starting the semester following successful completion of the oral comprehensive exam, students must enroll in accordance with the Office of Graduate Studies’ Doctoral Candidacy Policy. This enrollment includes, but is not limited to, at least 1 dissertation hour every semester until graduation and enrollment in at least 6 hours each fall & spring until meeting 18 hours post-comprehensive exam, after which, with the approval of the department, the student may reduce to a minimum of 1 dissertation hour each semester. See the Doctoral Candidacy policy for more information about this University level requirement.
In cases of exceptional research productivity and progress, mentors may suggest a Ph.D. defense and graduation earlier than 5 years.
Please visit with the MDCM Director of Graduate Studies and/or your advisor if you have questions
